In the U.S., about 4 million infants each year are tested by their state newborn screening program for Congenital Adrenal Hyperplasia (CAH), a life threatening form of adrenal insufficiency that affects 1 in 15,000 infants.
Boys and girls with CAH lack an enzyme the adrenal gland needs to make cortisol and aldosterone, hormones that are essential for life. These hormones help control blood pressure, blood sugar and heart function and are used by the body during times of stress, injury and infections.
Children with CAH require lifelong cortisol (steroid) replacement therapy. Current therapies are unable to replicate the normal peaks and valleys of cortisol secretion. This treatment gap can lead to abnormal/early puberty, short stature, polycystic ovarian syndrome, infertility, obesity, hypertension, osteoporosis, insulin resistance and children are at risk for life threatening seizures and death.
At the University of Minnesota, scientists are making strides in CAH research—working to develop better, more advanced treatments for patients. Donate now to support research for children with CAH. Your contributions will be magnified when we all join together.
To learn more about the CAH Clinic visit http://www.uofmchildrenshospital.org/Specialties/CAH/index.htm